Apolipoprotein-E mimetics
Scientists now at FXT discovered in 2004 that apolipoproteinE (apoE) plays a crucial role in regulating the clearance of cell debris by macrophages. As a result, FXT initiated a functional screening programme to identify small molecule mimetics of the apoE protein, which can stimulate clearance of cell debris.
The first family of such compounds has been identified and activities aiming to achieve a pre-clinical proof of concept are ongoing.