G-protein coupled receptors Agonist-Enriched
Libraries
FXT developed a technology (called GAEL) to generate proprietary libraries of novel small molecules which are enriched in agonists at a wide range of different G-protein coupled receptors (GPCRs). This technology is based on a cutting-edge multivariate QSAR study to identify the structural motifs that uniquely distinguish GPCR agonists from antagonists irrespective of the receptor being targeted. The libraries then present these motifs on scaffolds that have low intrinsic toxicity and excellent PK/PD properties.
Further development of this technology will be licensed-out.